2-Chloronicotinic acid
- CAS No.
- 2942-59-8
- Chemical Name:
- 2-Chloronicotinic acid
- Synonyms
- 2-CHLOROPYRIDINE-3-CARBOXYLIC ACID;CHLORONICOTINIC ACID;2-CHLORO-3-PYRIDINECARBOXYLIC ACID;2CLNA;2-Chloronicoti;2 - chloro niacin;AKOS BBS-00004231;oronicotinic acid;TIMTEC-BB SBB004002;RARECHEM AL BO 0287
- CBNumber:
- CB7714896
- Molecular Formula:
- C6H4ClNO2
- Molecular Weight:
- 157.55
- MDL Number:
- MFCD00006236
- MOL File:
- 2942-59-8.mol
- MSDS File:
- SDS
Melting point | 176-178 °C (dec.)(lit.) |
---|---|
Boiling point | 316.8±22.0 °C(Predicted) |
Density | 1.470±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO, Ethyl Acetate (Slightly) |
pka | 2.07±0.25(Predicted) |
form | Powder |
color | White to cream |
BRN | 119023 |
InChI | InChI=1S/C6H4ClNO2/c7-5-4(6(9)10)2-1-3-8-5/h1-3H,(H,9,10) |
InChIKey | IBRSSZOHCGUTHI-UHFFFAOYSA-N |
SMILES | C1(Cl)=NC=CC=C1C(O)=O |
LogP | 0.988 |
CAS DataBase Reference | 2942-59-8(CAS DataBase Reference) |
FDA UNII | 93G386213F |
EPA Substance Registry System | 2-Chloronicotinic acid (2942-59-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 22-24/25-37/39-26-36 | |||||||||
WGK Germany | 3 | |||||||||
TSCA | T | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29333999 | |||||||||
NFPA 704 |
|
2-Chloronicotinic acid price More Price(47)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 150339 | 2-Chloropyridine-3-carboxylic acid 99% | 2942-59-8 | 10g | $49.5 | 2024-03-01 | Buy |
Sigma-Aldrich | PHR2305 | Flunixin Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | 2942-59-8 | 50MG | $534 | 2024-03-01 | Buy |
Sigma-Aldrich | 1274629 | Flunixin Related Compound A United States Pharmacopeia (USP) Reference Standard | 2942-59-8 | 15mg | $596 | 2024-03-01 | Buy |
TCI Chemical | C1108 | 2-Chloronicotinic Acid >98.0%(HPLC)(T) | 2942-59-8 | 25g | $21 | 2024-03-01 | Buy |
TCI Chemical | C1108 | 2-Chloronicotinic Acid >98.0%(HPLC)(T) | 2942-59-8 | 250g | $99 | 2024-03-01 | Buy |
2-Chloronicotinic acid Chemical Properties,Uses,Production
Chemical Properties
white to cream powder. MP>175°C (decomposition), insoluble in water, soluble in organic solvents such as benzene and toluene.
Uses
2-Chloronicotinic Acid is used in the preparation of 4-thiazolidinone derivatives and Schiff bases displaying antimicrobial activity.
Application
2-Chloronicotinic acid is used in the synthesis of the anti-inflammatory and analgesic pralofen. It is an intermediate of the herbicides nicosulfuron and diflufenican. It is also used as pharmaceutical intermediates for the manufacture of mefenamic acid, niflumic acid, etc.
Preparation
Chloronicotinic acid was synthesized from nicotinic acid by oxidation by H2O2 and then chlorinationby POCl3 and PCl5 in a yield of 87.5%.
Synthesis of 2-chloronicotinic acid: Pour chlorine gas into the mixed solution of phosphorus oxychloride and phosphorus trichloride, control the temperature at about 60°C, until the remaining chlorine gas escapes, cool and add nicotinic acid N-oxide in batches, and heat the mixed solution. The reaction was carried out at 100-105°C for 1-1.5 h, and the reaction mixture was stirred for 30 min after the reaction mixture was transparent, and phosphorus oxychloride was removed under reduced pressure. The obtained residue was cooled to room temperature, and water was added to obtain the finished product of 2-chloronicotinic acid.
Definition
ChEBI: 2-Chloronicotinic acid is an aromatic carboxylic acid and a member of pyridines.
2-Chloronicotinic acid Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10319 | 58 |
Nanjing Hengbei Chemicals Co., Ltd. | +86-25-58393656 | sales@hengbeichem.cn | China | 6854 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21639 | 55 |
Changzhou Jiuwu Chemical co., Ltd. | +86-0519-85121086 +8613775162768 | info@jiuwuchem.cn | China | 75 | 58 |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20288 | 58 |
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View Lastest Price from 2-Chloronicotinic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-10-29 | 2-Chloronicotinic acid
2942-59-8
|
US $3.50 / kg | 1kg | ≥98% | 3000tons/month | Hebei Andu Technology Com.,Ltd | ||
2024-10-29 | 2-Chloronicotinic acid
2942-59-8
|
US $0.00 / KG | 1KG | 99% | 500mt | Jinan Finer Chemical Co., Ltd | ||
2024-10-25 | 2-Chloronicotinic acid
2942-59-8
|
US $0.00 / KG | 1KG | 0.99 | 5000kg | Hebei Yanxi Chemical Co., Ltd. |
- 2-Chloronicotinic acid
2942-59-8
- US $3.50 / kg
- ≥98%
- Hebei Andu Technology Com.,Ltd
- 2-Chloronicotinic acid
2942-59-8
- US $0.00 / KG
- 99%
- Jinan Finer Chemical Co., Ltd
- 2-Chloronicotinic acid
2942-59-8
- US $0.00 / KG
- 0.99
- Hebei Yanxi Chemical Co., Ltd.