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ChemicalBook >> CAS DataBase List >>Dextran Sulfate Sodium Salt

Dextran Sulfate Sodium Salt

CAS No.
9011-18-1
Chemical Name:
Dextran Sulfate Sodium Salt
Synonyms
DEXTRAN SULFATE SODIUM;DEXTRAN SULFATE;SODIUM DEXTRAN SULFATE;DEXTRAN SULPHATE SODIUM;SODIUM DEXTRAN SULFATE 5000;Dextran sulfate sodium salt - MW 9,000-11,000 - from Leuconostoc spp;asuro;ds-m-1;dexnon;DEXTRAN SULPHATE
CBNumber:
CB9339022
Molecular Formula:
(C6H7Na3O14S3)n
Molecular Weight:
0
MDL Number:
MFCD00081551
MOL File:
Mol file
MSDS File:
SDS
Last updated:2024-10-28 23:16:16

Dextran Sulfate Sodium Salt Properties

storage temp. room temp
solubility H2O: 100 mg/mL
form powder
color White to off-white
PH pH(50g/l, 25℃)4.5~8.0
Water Solubility Soluble in water.
Merck 2951
InChI InChI=1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3
InChIKey BLFLLBZGZJTVJG-UHFFFAOYSA-N
SMILES C(OCC)(=O)C1=CC=C(N)C=C1
EWG's Food Scores 1
EPA Substance Registry System Dextran, hydrogen sulfate, sodium salt (9011-18-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P261
Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36-37/39-24/25
WGK Germany  2
RTECS  HH9290000
3-10
TSCA  Yes
HS Code  39139000

Dextran Sulfate Sodium Salt price More Price(154)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S4031 Dextran Sulfate 50% Solution 9011-18-1 200ML $369 2024-03-01 Buy
Sigma-Aldrich 31404 Dextran sulfate sodium salt from Leuconostoc spp. Mr 5,000 9011-18-1 5G $61.1 2024-03-01 Buy
Sigma-Aldrich 31404 Dextran sulfate sodium salt from Leuconostoc spp. Mr 5,000 9011-18-1 25g $292 2024-03-01 Buy
Sigma-Aldrich 265152-M Dextran Sulfate, Sodium Salt, Molecular Biology Grade - CAS 9011-18-1 - Calbiochem Used to accelerate hybridization of DNA probes to immobilized nucleic acids. 9011-18-1 265152-10GM $95.8 2024-03-01 Buy
Sigma-Aldrich 265152-M Dextran Sulfate, Sodium Salt, Molecular Biology Grade - CAS 9011-18-1 - Calbiochem Used to accelerate hybridization of DNA probes to immobilized nucleic acids. 9011-18-1 265152-50GM $318 2024-03-01 Buy
Product number Packaging Price Buy
S4031 200ML $369 Buy
31404 5G $61.1 Buy
31404 25g $292 Buy
265152-M 265152-10GM $95.8 Buy
265152-M 265152-50GM $318 Buy

Dextran Sulfate Sodium Salt Chemical Properties,Uses,Production

Description

Dextran sulfate (dextran hydrogen sulfate, sodium salt) has been tested as a potential substitute for heparin in anticoagulant therapy. Following studies by Ingelman, Walton and Ricketts explored the anticoagulant properties of a wide range of dextran sulfates (Mw 7000 to 458000) and established that the lowest molecular weight products displayed the highest anticoagulant properties. However, at best this only represented 15% of heparin's activity.
With the introduction of low-dose heparin therapy for thrombosis prophylaxis in the 70's, interest in low molecular weight polyanions has been rekindled and reports on interactions with individual enzyme/inhibitor systems in the coagulation cascade have appeared.
Dextran sulfate immobilized on cellulose has been found to remove LDL cholesterol preferentially during plasmaphoresis.
Its wide spectrum of biological properties has attracted the attention of many scientists. The reports may be grouped according to the following biological effects.

  • Enzyme inhibition, activation and release
  • Adjuvant effect on immune response
  • Cellular interactions and response
  • Effect on virus infectivity

Uses

  1. Dextran sulfate is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule. Dextran sulfate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The high purity and reproducible quality enables its application in pharmaceuticals and biotechnology industry.
  2. Dextran sulfate is used asa nucleic acid hybridization accelerant. The polyanionic character of Dextran sulfate helps to approximate nucleic acid strands, increasing their effective concentration to each other and promoting hybridization. Dextran sulfate also demonstrates a sequestering interaction with proteins, presumably through hydrogen-bonding between the sulfate groups and amine groups of the protein that generates an insoluble complex. The ability of the polymer to precipitate fibrinogen and low-density lipoproteins from plasma solutions has been used for analysis and for anticoagulant applications. Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate.
  3. Dextran sulfate sodium shows immunologically relevant activities: enhancement and suppression of humoral immunity, polyclonal activation of B-lymphocytes, stimulating even immature B cells, changes in thymocyte reactivity to lectins, enhancement/suppression of cell-mediated immune responses. Precipitates LDL and VLDL lipoproteins - in the presence of magnesium ions, dextran sulfate precipitates low-density lipoproteins from human serum leaving the high-density lipoproteins in the supernatant. Removal of lipoproteins by dextran sulfate precipitation may be useful in the purification of other materials such as beta 2 glycoprotein.

Toxicity

The toxicity of these products had been recognized at an early stage. Nevertheless, a low molecule weight fraction with Mw 7000 and S, 16% was considered to be qualitatively similar to heparin. Preliminary clinical trials were unfortunately discouraging and revealed severe adverse reactions, notably, stiff and painful joints, skin eruption, loss of hair and gastro-intestinal symptoms. In chronic toxicity studies in animals, retardation in weight gain and osteoporosis with spontaneous fractures were observed. It should be noted that the doses in the clinical trials corresponded to 1.3 g/day, which is approximately tenfold that used in current heparin therapy.
More recently attention has been focussed on the toxicity of orally administered substance. Supplements of 0.25% and 0.5% for 82 weeks in rats did not increase the incidence of infection or tumours. Higher doses (1–10%) resulted in mortality and tumours. Apart from dosage, the toxicity is also dependent on Mw. Adsorption studies in the gut using a wide range of dextran sulfates (3000–200000) suggest only a small proportion of the dose is absorbed. Intravenous administration has also been investigated. The inhibition of metastasis by dextran sulfate (Mw 6–7 x 10 3 , DS approx. 2) has been tested clinically but the 5 year survival rate in lung cancer was not improved. Tests for mutagenicity and cytogenicity of low MW dextran sulfate proved negative.

Chemical Properties

White to off-white powder

Uses

Clinical studies indicate a possible capacity of dextran sulfate to reduce edema. It is cited as a binder and skin conditioner.

Uses

Clinical reagent (HDL cholesterol determination).

Uses

Dextran sulfate sodium salt Leuconostoc spp has been used:

  • as a standard to perform polyacrylamide-gel electrophoresis for carbohydrates (C-PAGE)(59) and agarose gel electrophoresis(60)
  • for RNA sequential probing of targets (SPOTs) imaging(61)
  • as a component of 1% injection buffer(62)

Definition

ChEBI: Benzocaine is a benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina. It has a role as a topical anaesthetic, an antipruritic drug, an allergen and a sensitiser. It is a benzoate ester and a substituted aniline.

General Description

Dextran sulfate is a sulfated polysaccharide, which is negatively charged. It is produced by the esterification of dextran with chlorosulphonic acid. Dextran is used to treat hemorrhage, burns, surgery and trauma. It improves blood flow and prevents erythrocyte aggregation. Dextran lowers the risk of thrombosis and postoperative pulmonary emboli. It is a ribonuclease inhibitor. Dextran sulfate exhibits antiviral, anticoagulant and adjuvant properties.

Biochem/physiol Actions

Dextran is a mixture of glucose polymers of varying size and geometry.Dextran in the form of dextran sulphate sodium acts as an anticoagulant. Dextran interferes with blood clot formation by acting on blood coagulation factors and the function of platelets. It prolongs the time required for formation of the clot and decreases the maximum clot strength. The disturbance of homeostasis by dextran may cause increased bleeding, colitis and kidney failure.

Dextran Sulfate Sodium Salt Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 387)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Deshang Chemical Co., Ltd.
+86-0531-8875-2665 +8613153039501 info@deshangchem.com China 660 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810 1022@dideu.com China 3882 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12795 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850 info@fortunachem.com China 5986 58
Shanghai Joiny Pharmaceutical Co.,LTD
+8613681955282 gyd@joiny-pharma.com China 254 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2472 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652 info@fdachem.com China 20288 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651 admin@zlchemi.com China 3002 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
+86-15350851019 +86-15383190639 admin@86-ss.com China 1000 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21639 55

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View Lastest Price from Dextran Sulfate Sodium Salt manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dextran Sulfate Sodium Salt pictures 2024-10-29 Dextran Sulfate Sodium Salt
9011-18-1
US $0.00-0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
Dextran Sulfate Sodium Salt pictures 2024-10-29 Dextran Sulfate Sodium Salt
9011-18-1
US $10.00 / kg 1kg 99% 20ton Hebei Zhuanglai Chemical Trading Co.,Ltd
Dextran Sulfate Sodium Salt pictures 2024-10-29 Dextran Sulfate Sodium Salt
9011-18-1
US $99.00-66.00 / kg 0.0010000000474974513kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Dextran,hydrogensulfate,sodiumsalt dextransodiumsulfate dextransulfateso-saltfromleuconostocssp. dextrarine dexulate mds(polysaccharide) DEXTRAN SULFATE SODIUM MOLECULAR*BIOLOGY REAGENT DEXTRAN SULFATE SODIUM SALT, FROM LEUCONOSTOC SSP. DEXTRAN SULFATE SODIUM AV. MOL. WT. OF*5 00,000 DEXTRAN SULFATE SO-SALT FROM LEUCONOSTOC SSP., MR ~500000 DEXTRAN SULFATE SODIUM SALT FROM LEUCONOSTOC SSP., MW 100'000 DEXTRAN SULFATE SODIUM SALT FROM LEUCONOSTOC SPP. DEXTRAN SULFATE SODIUM AV. MOL. WT.*APPR OX. 8,000 DextranSulfate500,000Mw DEXTRANSULFATE,50%SOLUTION,STERILE,BIOTECHGRADE DEXTRANSULFATESODIUMSALT,POWDER DEXTRANSULFATESODIUMSALT,POWDER,HEAVY DEXTRANSULFATESODIUMSALT,POWDER,LIGHT extran sulfate sodium DEXTRAN SULFATE SODIUM (FROM DEXTRAN OF MW. APPROX. 2.500) DEXTRAN SULFATE SODIUM (FROM DEXTRAN OF MW. APPROX. 4.000) DEXTRAN SULFATE SODIUM (FROM DEXTRAN OF MW. APPROX. 25.000) Dextran Sulfate 2000 Dextran Sulfate 3000 Dextran Sulfate 40,000 Dextran Sulfate 50,000 Dextran sulfate 500,000 Dextran Sulfate 5000 DEXTRAN SULPHATE extrapure DEXTRAN SULFATE AV. MOL. WT. 5,000*(LALL S) Dextran sulphate sodium from leuconostoc 500,000 Dextran Sulfate 10,000 Dextran sulfate sodium salt from Dextran of Mw. Approx. 15,000 Dextran sulfate sodium salt from Dextran of Mw. Approx. 10,000 Dextran sulfate sodium salt from Dextran of Mw. Approx. 1,500 Isomalto oligosaccharide sulfate1500 Isomalto oligosaccharide sulfate3000 Dextran sulfate sodium from Dextran of Mw. Approx. 10,000 Dextran sulfate sodium from Dextran of Mw. Approx. 15,000 Dextran sulfate sodium from Dextran of Mw. Approx. 20,000 Dextran sulfate sodium from Dextran of Mw. Approx. 40,000 Dextran sulfate sodium from Dextran of Mw. Approx. 50,000 ACRYL/BIS 19:1 ULTRA PURE GRADE Dextran sulfate sodium from Dextran of Mw. Approx. 5,000 Dextran sulfate sodium from Dextran of Mw. Approx. 8,000 DEXTRAN SULFATE SODIUM AV. MOL. WT. DEXTRAN SULFATE SODIUM MOLECULAR*BIO DEXTRAN SULFATE SODIUM SALT FROM LEU DEXTRAN SULFATE SODIUM SALT LEUCONOS Dextran sulfate sodium salt, Mw~ 80000 Dextran sulfate sodium salt, Mw~ 8,000 Dextran sulfate sodium salt, Mw~ 500,000 Dextran Sulfate, Sodium Salt, Molecular Biology Grade Dextran sulfate sodium salt, approx. M.W. 6, 500 - 10, 000 SODIUM DEXTRAN SULFATE 500,000 DEXSATEMPO(TM) DEXTRALIP(R) 50 DEXTRAN SULFATE 500 NA-SALT